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A mitochondrial-derived peptide studied for its role in cellular metabolism, energy regulation, and metabolic signaling pathways. MOTS-c continues to be investigated for its unique relationship between mitochondrial signaling and cellular function. For laboratory research use only.
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MOTS-c is one of the few peptides coded by mitochondrial DNA rather than the nucleus. Its 16 residues are read from a short open reading frame inside the MT-RNR1 gene, the stretch that also encodes the mitochondria's 12S ribosomal RNA. That origin is why MOTS-c peptides sit at the center of research on how mitochondria signal to the rest of the cell, from muscle metabolism to stress responses in the lung and liver.
Here's why the sequence matters so much. In 2024, iScience reported that MOTS-c works through the kinase CK2, and that K14Q MOTS-c, a naturally occurring variant with glutamine in place of lysine at position 14, binds CK2 poorly and fails to activate it or produce its effects. A vial is only as useful as its sequence is exact. Titan Core publishes the full sequence below, and every batch goes to an independent lab for HPLC purity and mass spectrometry, which catches missing, extra or swapped residues that shift the chain's weight. It's made in the USA, and the report you can download here carries the same LOT number as your vial. MOTS-c is sold for laboratory research only and isn't for human or animal use.
Research Highlights
FORM: Lyophilized powder
PURITY: ≥99% (HPLC verified)
SEQUENCE: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg (MRWQEMGYIFYPRKLR)
MOLECULAR FORMULA: C₁₀₁H₁₅₂N₂₈O₂₂S₂
MOLECULAR WEIGHT: 2174.6 g/mol
CAS NUMBER: 1627580-64-6
PRESENTATION: 10mg · 20mg
LOT: Manufacturer LOT
STORAGE: Store lyophilized at –20°C, protected from light and moisture.
A 16-amino-acid peptide (MRWQEMGYIFYPRKLR) encoded by mitochondrial DNA and found naturally in human blood and tissue.
In research it's treated as a mitochondrial messenger, with studies tracking its effects on muscle metabolism, membrane repair and cellular stress responses.
Different families entirely. Retatrutide is a lipidated drug candidate that activates three hormone receptors; MOTS-c is a short, unmodified peptide the mitochondria make themselves.
No powder is pure peptide. MOTS-c has five basic sites that carry counterions, so theory puts peptide at roughly 79% of the powder as a TFA salt or 88% as an acetate salt. Purity and peptide content are separate measurements.
Match the report's LOT to your vial, then compare its mass result with the molecular weight in Product Details. If the two LOT numbers don't agree, message support before you open the vial.
It has no approval for human use and no established safety profile in people. Titan Core doesn't advise on mots c side effects or dosing; it's supplied for laboratory research only.
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