SEMAX

Semax is built from a stress hormone. Its first four residues, Met-Glu-His-Phe, are positions 4–7 of adrenocorticotropic hormone (ACTH), and a Pro-Gly-Pro tail completes the heptapeptide MEHFPGP. Russian researchers developed it as a synthetic analog of the ACTH(4–10) fragment, and in 2011 it was placed on Russia's List of Vital and Essential Drugs. That clinical history is why semax peptides appear across stroke, spinal cord, inflammation and brain-connectivity research, far more than most nootropic compounds.

The weak point is the chain's front end. Enzymes in blood degrade Semax starting at the N-terminus, and a vial exposed to moisture, warmth or repeated handling can end up holding a mix of shorter fragments. A degraded vial doesn't just underperform; it changes what's actually being studied. Forum threads blame Semax's split results on "fakes"; often the cleaner explanation is a chain that's no longer intact. Intact Semax weighs 813.9 Da, while its Pro-Gly-Pro tail alone weighs 269.3, so mass spectrometry shows at once whether the full chain is present. Titan Core's Semax is made in the USA, and each production lot is analyzed for identity and content by an independent lab before it's listed, with a report tied to your vial's LOT. Semax is sold for bench research alone and must never be given to people or animals.

Research Highlights

• Brain connectivity — In 52 healthy participants, resting-state fMRI showed Semax and Selank each altered connectivity between the right amygdala and right temporal cortex (Doklady Biological Sciences, 2020).
• Spinal cord injury — In injured mice, Semax improved functional recovery and curbed lysosomal-damage pyroptosis, acting through USP18 with the μ-opioid receptor identified as its target (British Journal of Pharmacology, 2025).
• Stroke transcriptome — Twenty-four hours after rat cerebral ischemia, Semax altered 1,539 genes and helped correct ischemia-driven distortions in 1,171 immune and signaling genes (Biomedicines, 2024).
• Inflammatory transcripts — In the same ischemia model, Semax significantly lowered Il1a, Il1b, Il6, Ccl3 and Cxcl2 mRNA (Molecular Biology, 2021).
• Copper chelation — Semax binds Cu(II) strongly enough to pull it from copper-amyloid-β complexes and cut the reactive oxygen species they generate (Bioinorganic Chemistry and Applications, 2025).
• Receptor-binding methods — Radiolabeled Semax served as the model peptide for mapping binding to brain-cell membranes and allosteric effects on other neuroreceptors (Journal of Labelled Compounds and Radiopharmaceuticals, 2019).
• Dopaminergic axon model — A mouse MPTP model of nigrostriatal axon degeneration was validated using Semax as a reference neuroprotector (Acta Naturae, 2021).

FORM: Lyophilized powder
PURITY: ≥99% (HPLC verified)
SEQUENCE: Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP, unmodified)
MOLECULAR FORMULA: C₃₇H₅₁N₉O₁₀S
MOLECULAR WEIGHT: 813.9 g/mol
CAS NUMBER: 80714-61-0
PRESENTATION: 10mg
LOT: TC-071-JZ
STORAGE: Store lyophilized at –20°C; protect from light.