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A triple-receptor agonist studied for its activity at GLP-1, GIP, and glucagon receptors. Our Retatrutide is supplied as a high-purity research peptide with independent testing for identity and purity. For laboratory research use only.
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Retatrutide (LY3437943) is Eli Lilly's single molecule that activates three receptors: GIP, GLP-1 and glucagon. Hence the GLP-3 retatrutide nickname, though no hormone called GLP-3 exists. A C20 fatty-acid chain on lysine 17 lets it ride on albumin for days. Lilly's phase 3 TRIUMPH program is testing it at scale, with TRIUMPH-1 and TRIUMPH-3 reaching primary completion in April 2026.
That fame brings copies. A 2026 preprint by Mendias and Awan, covering 6,441 independent test reports, found 59 retatrutide samples that didn't contain retatrutide, the most of any compound. Australia's TGA reported in September 2026 on a vial sold as retatrutide that held semaglutide. No substitute matches retatrutide's mass with that lipid chain attached, so mass spectrometry exposes a swap at once. Titan Core makes retatrutide in the USA and tests every batch for identity and purity by mass spec and HPLC; the downloadable report carries your vial's LOT number. Some sellers list this compound under code names without naming the molecule. We publish its name, sequence and CAS. It's for laboratory research only, not for human or animal use.
Research Highlights
FORM: Lyophilized powder
PURITY: ≥99% (HPLC verified)
SEQUENCE: Tyr-Aib-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-αMeLeu-Leu-Asp-Lys-Lys(AEEA-γGlu-C20 diacid)-Ala-Gln-Aib-Ala-Phe-Ile-Glu-Tyr-Leu-Leu-Glu-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂
MOLECULAR FORMULA: C₂₂₁H₃₄₂N₄₆O₆₈
MOLECULAR WEIGHT: 4731.4 g/mol
CAS NUMBER: 2381089-83-2
PRESENTATION: 10mg · 20mg · 30mg · 50mg
LOT: TC-079-JZ
STORAGE: Store lyophilized at –20°C, protected from light and moisture.
A synthetic 39-amino-acid peptide from Eli Lilly, coded LY3437943, that activates GIP, GLP-1 and glucagon receptors from one molecule.
Researchers use it to study three metabolic pathways at once: insulin and appetite signaling through GIP and GLP-1, and energy expenditure through glucagon.
Tirzepatide stops at two receptors, GIP and GLP-1. Retatrutide adds the glucagon receptor, giving researchers an energy-expenditure pathway tirzepatide doesn't touch.
Only partly. Ozempic's semaglutide works on the GLP-1 receptor alone; retatrutide hits three receptors and is a different, heavier molecule.
Download the report here and match its LOT to your vial. HPLC shows purity; the mass result confirms retatrutide rather than another GLP-1 peptide. If the LOTs differ, contact support before opening it.
Questions about retatrutide side effects are answered by Lilly's clinical trials, not by a research vial. Titan Core's retatrutide is a research compound, not an approved medicine, and we don't give dosing or safety guidance for people.
Right here. To buy retatrutide, register, pick a size and check out. Our retatrutide for sale is USA-made, and weekday orders placed by 4 PM EST ship the same day.
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