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Melanotan II is α-MSH cut down to seven residues and locked into a ring, so one molecule switches on four melanocortin receptors. Titan Core lists its full cyclic sequence and prints a manufacturer LOT on every vial, so you can match it to its report.
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The Melanotan II peptide, or MT-2, is a ring closed by a lactam bridge between aspartic acid and lysine, and it activates MC1, MC3, MC4 and MC5 alike. That breadth is why labs keep it on the shelf: a 2024 review in ACS Pharmacology & Translational Science names MTII among the core tool compounds for validating melanocortin receptor cell lines, solving cryo-EM structures and anchoring high-throughput screens.
The problem is what's actually in the vial, and guessing from forum "reactions" can't settle it. In 2024, forensic toxicologists in Liège confirmed a vial labelled Melanotan II held genuine MT-II at only 30% purity. Milligrams drift too: reports we read for three other sellers' "10 mg" vials measured 9.1, 11.1 and 12.4 mg. Titan Core's MT-2 is third-party tested to 99%+ HPLC purity, and each vial's manufacturer LOT ties to its lab report; if yours isn't posted yet, ask Contact Support before opening. Sold as a lab reagent; never for use in people or animals.
Research Highlights
A synthetic cyclic heptapeptide based on α-MSH, with an acetylated start, an amidated end and a D-phenylalanine where the natural hormone has the L form.
Receptor pharmacology, sensor and screening work, and brain-circuit and pigment-cell models.
Melanotan I (afamelanotide) is a linear 13-residue peptide that leans toward MC1 and is an approved drug. Melanotan II is a seven-residue ring that hits four receptors.
Bremelanotide (PT-141) is MT-II with a free acid in place of the terminal amide, about 1 Da heavier at 1,025.2. Forensic labs separate them by high-resolution mass spectrometry (Drug Testing and Analysis, 2021).
Check three lines on the report: purity, an identity result from mass spectrometry, and measured milligrams. MT-II often shows up as a doubly charged ion near m/z 513 rather than at 1,024; that's the same molecule.
You can buy Melanotan II here, with its full cyclic sequence listed. If it shows out of stock, Contact Support will let you know when the next LOT lands.
It has never been approved by the FDA, and medical journals have published a run of case reports tied to unlicensed use since 2025. Our MT-2 is sold as a research reagent, with no guidance on dosing or effects in people.
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