TIRZEPATIDE / GLP-2 TRZ

Tirzepatide is one molecule that works two incretin receptors, GIP and GLP-1, the standard reference for testing what a second receptor adds. Titan Core sells it as tirzepatide alone, with the formula and full lipidated mass listed so any lab report can be checked against it.

Tirzepatide / GLP-2 TRZ
Out of Stock
For Research Purposes Only
Price $35.99
Size:10MG
Lab report (COA) pending for this out-of-stock product. Will be posted when available.
  • Third-Party Tested - (COA) Available
  • Free 2-Day Shipping on Orders $49.99
  • Tirzepatide Alone, Nothing Blended In

Overview

Tirzepatide is a 39-residue peptide built on the GIP hormone backbone and tuned to reach the GLP-1 receptor as well, with a C20 fatty diacid chain on lysine 20 that lets it ride on albumin. Labs use it to pull the two receptors' jobs apart: in a 2021 Journal of Clinical Investigation study, tirzepatide still improved insulin sensitivity in obese mice lacking the GLP-1 receptor, pointing to GIP receptor action in white fat.

The worry is whether a vial holds only tirzepatide. A 2026 Annals of Pharmacotherapy survey of 33 unusual compounded semaglutide and tirzepatide products found 48% mixed the peptide with extras such as cyanocobalamin, glycine or ondansetron. The lipid chain is the other weak point: without it, the backbone weighs about 4,070 Da instead of 4,813.5, and a purity percentage won't flag that. One competitor sells its tirzepatide in four strengths but posts reports for only two. Titan Core's vial holds tirzepatide alone, its lipidated weight is listed below, and each manufacturer LOT ties to a lab report; if yours isn't posted yet, ask Contact Support first. Lab research only; it isn't a stand-in for the branded drugs.

Research Highlights

  • Receptor bias studies — It matched native GIP at the GIP receptor but, at the GLP-1 receptor, bound 5-fold weaker and signalled cAMP 20-fold less potently than GLP-1, with under 10% arrestin recruitment (JCI Insight, 2020).
  • Metabolism tracing — Carbon-14 tracing in humans, rats and monkeys found about 66% of radioactivity in urine, no intact peptide in excreta, and beta-oxidation of the C20 diacid (European Journal of Pharmaceutical Sciences, 2024).
  • Heart failure models — Over 14 days in angiotensin II-infused mice, tirzepatide reduced mortality and preserved cardiac function, compared with liraglutide (Cardiovascular Diabetology, 2025).
  • Blood pressure research — In stroke-prone spontaneously hypertensive rats, tirzepatide raised mean blood pressure to 197.4 mmHg against 153.7 in pair-fed controls at day 28, with signs of sympathetic activation (Hypertension Research, 2026).
  • Vascular injury models — 4 weeks after wire injury, tirzepatide limited intimal thickening in non-diabetic mice through a nitric-oxide-dependent route, where semaglutide at the same molar dose did not (Biomedicines, 2026).
  • Neurodegeneration models — In 6-month-old 5XFAD mice, neither tirzepatide nor semaglutide reduced amyloid pathology or improved cognition (Molecular Metabolism, 2024).

Product Details

  • FORM: Lyophilized powder
  • PURITY: ≥99% (HPLC verified)
  • SEQUENCE: Tyr-Aib-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Ile-Aib-Leu-Asp-Lys-Ile-Ala-Gln-Lys(γGlu-2xAEEA-C20 diacid)-Ala-Phe-Val-Gln-Trp-Leu-Ile-Ala-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH₂
  • MOLECULAR FORMULA: C₂₂₅H₃₄₈N₄₈O₆₈
  • MOLECULAR WEIGHT: 4813.53 g/mol
  • CAS NUMBER: 2023788-19-2
  • PRESENTATION: 10mg per vial
  • LOT: Manufacturer LOT
  • STORAGE: Store lyophilized at –20°C, protected from light and moisture.

Frequently Asked Questions

A dual agonist peptide that activates the GIP and GLP-1 receptors. It isn't insulin; it acts upstream of insulin release.

It acts on GLP-1 and GIP receptors. "GLP-2 TRZ" is a nickname for its two receptors and has nothing to do with glucagon-like peptide-2, a separate hormone.

Two Aib residues for stability, plus a γGlu and two AEEA spacers linking the fatty diacid. In this vial, nothing else.

Its development code is LY3298176. Mounjaro and Zepbound are brand names of the approved drug; this research compound is neither.

You can buy tirzepatide here, single-ingredient, with its structure listed. If it shows out of stock, Contact Support will flag you for the next LOT.

The approved drugs carry their own prescribing warnings; this research compound isn't labeled for use in people or animals. Titan Core offers no dosing or side-effect guidance for it.

Related Products

YOU MAY ALSO LIKE

Retatrutide / GLP-3-RT
For Research Purposes Only

Retatrutide / GLP-3-RT

From $79.99

A triple-receptor agonist studied for its activity at GLP-1, GIP, and glucagon receptors. Our Retatrutide is supplied as a high-purity research peptide with independent testing for identity and purity. For laboratory research use only.

  • Third-Party Tested - (COA) Available
  • Free 2-Day Shipping on Orders $49.99
  • Lipidated Lysine-17 Side Chain Specified
View Product
MOTS-C
For Research Purposes Only

MOTS-C

From $32.99

A mitochondrial-derived peptide studied for its role in cellular metabolism, energy regulation, and metabolic signaling pathways. MOTS-c continues to be investigated for its unique relationship between mitochondrial signaling and cellular function. For laboratory research use only.

  • Third-Party Tested - (COA) Available
  • Free 2-Day Shipping on Orders $49.99
  • Unmodified Native Peptide, No Analog Swaps
View Product
BPC-157 + TB-500
For Research Purposes Only

BPC-157 + TB-500

From $69.99

A research blend combining BPC-157 and TB-500, two peptides commonly investigated in tissue and cellular research. Each batch is independently tested to verify identity, composition, and purity. For laboratory research use only.

  • Third-Party Tested - (COA) Available
  • Free 2-Day Shipping on Orders $49.99
  • Two Mechanisms, One Fixed Ratio
View Product